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M94A2667.TXT
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1994-10-25
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Document 2667
DOCN M94A2667
TI HIV vertical transmission in Buenos Aires: follow-up.
DT 9412
AU Laube G; Canizal AM; Zarwanitzer S; Hirsch R; Sosa CE; Benetucci J;
Muniz H; FUNDAI y Pediatria, Buenos Aires, Argentina.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):252 (abstract no. PB0439). Unique
Identifier : AIDSLINE ICA10/94369908
AB OBJECTIVE: To determine the HIV vertical transmission rate in Buenos
Aires, Argentina and to assess HIV co-culture and p24 Antigen detection
in early diagnosis of pediatric AIDS. METHODS: Thirty seven children
born to HIV seropositive mothers were enrolled and prospectively
followed until they reached 18 months of age to determine HIV infection.
All children were in a PO clinical status according to CDC at the moment
of enrollment. Children were studied by EIA (Abbot) and Immunoblot
(Novapath, Blorad) for HIV antibody detection. Virus co-culture and p24
Antigen detection (Organon Teknika) were performed in all the samples.
RESULTS: Nine out of 37 (24.32%) children were infected after 18 months
of follow up according to HIV antibody detection meanwhile seroreverter
children lost their antibodies between 7 to 10 months (mean 8.3). Eight
out of 37 (21.6%) children were positive for virus co-culture and 6/37
(15.8%) had p24 Antigen detected. Two children out of the ten infected
developed AIDS Defining Condition: one lymphoid interstitial pneumonia
and one sepele by Salmonella (deceased) and 37.5% of the infected
children presented symptomatology before 12 month of age. Mothers' risk
factors were: 37.66% intra venous drug users and 63.4% heterosexual
transmission. CONCLUSIONS: The HIV1 vertical transmission rate is 24.32%
for this population. HIV co-culture showed a good correlation with
follow up and antigen is a valuable alternative although not as
sensitive as co-culture. This preliminar report shows lower figures than
other communications.
DE Argentina AIDS Serodiagnosis *Developing Countries Female Follow-Up
Studies Human HIV Core Protein p24/BLOOD HIV
Infections/DIAGNOSIS/*TRANSMISSION HIV
Seropositivity/DIAGNOSIS/*TRANSMISSION Infant Infant, Newborn
Pregnancy Pregnancy Complications, Infectious/*DIAGNOSIS Prospective
Studies MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).